Researchers at the University of Basel have developed a new synthesis approach for the manufacture of complex natural substances with the ingredients for treatments for various illnesses. According to a press release, many natural substances contain properties that form the basis for new active substances in medicine.
Terpenes form a group of substances that have already been used in treatments against cancer, epilepsy, and malaria, for example. They occur in plants, insects, and sea sponges. However, a vital prerequisite for the further development of drugs is that these terpenes must be created fully synthetically. This enables the determination of their precise molecular structures and changes to be made to them in a targeted way to optimize their properties for use as medication.
Chemist Olivier Baudoin and PhD student Oleksandr Vyhivskyi have now developed a synthetic pathway and created two terpenes belonging to the subgroup of diterpenes: randainin D and barekoxide. They have published a report on this in the Journal of the American Chemical Society.
Randainin D comes from plants and inhibits the production of an enzyme that plays a part in illnesses such as rheumatoid arthritis, cystic fibrosis, and chronic obstructive pulmonary disease. This makes it a possible candidate for therapeutic agents. The chemists created randainin D in 17 synthesis steps. This involved photocatalysis, which uses light energy to trigger chemical reactions. Professor Baudoin commented: “Our results show the potential of photocatalysis for the total synthesis of complex terpenes. This could pave the way for the development of new medications.” The researchers subsequently used the same synthesis method to create barekoxide.
